Edetate Disodium
Excipient (pharmacologically inactive substance)
What is it?
Edetate calcium disodium ([CH2N(CH2CO2H)2]2, also known as calcium EDTA or edetate disodium) is a chelating agent, and is capable of removing a heavy metal, such as lead or mercury, from the blood circulatory system. Edetate calcium disodium is used to treat lead poisoning. These agents also function as chelating agents in cosmetic formulations. Clinical tests reported no absorption of an EDTA salt through the skin, and the Cosmetic Ingredient Review Expert Panel found that these ingredients are safe as used in cosmetic formulations. In industry, EDTA is mainly used to sequester metal ions in aqueous solution, and to improve stability.[1][2]
[1] [1]Lanigan RS, Yamarik TA. Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. Int J Toxicol. 2002;21 Suppl 2:95-142. http://www.ncbi.nlm.nih.gov/pubmed/12396676
[2] [2]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
Top Medications with this excipient
- Amnesteem 10 mg (Mylan Pharmaceuticals Inc.)
- Amnesteem 20 mg (Mylan Pharmaceuticals Inc.)
- Amnesteem 40 mg (Mylan Pharmaceuticals Inc.)
- Claravis 30 mg (Teva Pharmaceuticals)
- ConRx Sinus acetaminophen 325 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg (Eagle Distributors,Inc.)
- Enjuvia 0.3 mg (Barr Laboratories, Inc.)
- Enjuvia synthetic B, 0.45 mg (Barr Laboratories, Inc.)
- Enjuvia synthetic B, 0.625 mg (Barr Laboratories, Inc.)
- Enjuvia synthetic B, 1.25 mg (Barr Laboratories, Inc.)
- Myorisan 20 mg (VersaPharm Incorporated)
- Myorisan 10 mg (VersaPharm Incorporated)
- Myorisan 40 mg (VersaPharm Incorporated)
- Promethazine HCl 12.5 mg (Qualitest Pharmaceuticals Inc.)
- Promethazine Hydrochloride 25 mg (Qualitest Pharmaceuticals Inc.)
- Sotret 10 mg (Ranbaxy Pharmaceuticals Inc.)
- Tretinoin 10 mg (Par Pharmaceutical Inc.)
- Tretinoin 10 mg (Teva Pharmaceuticals USA)
- Xifaxan 550 mg (Salix Pharmaceuticals, Inc)
- Zenatane 20 mg (Dr. Reddy's Laboratories Limited)
- Zenatane 40 mg (Dr. Reddy's Laboratories Limited)
