Edetate Disodium
Excipient (pharmacologically inactive substance)
What is it?
Edetate calcium disodium ([CH2N(CH2CO2H)2]2, also known as calcium EDTA or edetate disodium) is a chelating agent, and is capable of removing a heavy metal, such as lead or mercury, from the blood circulatory system. Edetate calcium disodium is used to treat lead poisoning. These agents also function as chelating agents in cosmetic formulations. Clinical tests reported no absorption of an EDTA salt through the skin, and the Cosmetic Ingredient Review Expert Panel found that these ingredients are safe as used in cosmetic formulations. In industry, EDTA is mainly used to sequester metal ions in aqueous solution, and to improve stability.[1][2]
[1] [1]Lanigan RS, Yamarik TA. Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. Int J Toxicol. 2002;21 Suppl 2:95-142. http://www.ncbi.nlm.nih.gov/pubmed/12396676
[2] [2]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
Top Medications with this excipient
- Clarinex-D 24 Hour 5 mg / 240 mg
- ConRx Allergy Sinus acetaminophen 325 mg / chlorpheniramine maleate 2 mg / phenylephrine hydrochloride 5 mg
- ConRx Cold acetaminophen 325 mg / dextromethorphan hydrobromide 10 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg
- ConRx Sinus acetaminophen 325 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg
- Enjuvia synthetic B, 0.625 mg
- Enjuvia synthetic B, 0.45 mg
- Methyldopa 500 mg
- Methyldopa 250 mg
- Myorisan 10 mg
- Myorisan 20 mg
- Pain Relief PM Extra Strength acetaminophen 500 mg / diphenhydramine 25 mg
- Phenelzine Sulfate 15 mg
- Promethazine HCl 12.5 mg
- Promethazine Hydrochloride 50 mg
- Promethazine Hydrochloride 25 mg
- Sotret 10 mg
- Tretinoin 10 mg
- Xifaxan 550 mg
- Zenatane 20 mg
- Zenatane 10 mg
