Edetate Disodium
Medically reviewed by Drugs.com. Last updated on Jul 9, 2021.
Excipient (pharmacologically inactive substance)
What is it?
Edetate calcium disodium ([CH2N(CH2CO2H)2]2, also known as calcium EDTA or edetate disodium) is a chelating agent, and is capable of removing a heavy metal, such as lead or mercury, from the blood circulatory system. Edetate calcium disodium is used to treat lead poisoning. These agents also function as chelating agents in cosmetic formulations. Clinical tests reported no absorption of an EDTA salt through the skin, and the Cosmetic Ingredient Review Expert Panel found that these ingredients are safe as used in cosmetic formulations. In industry, EDTA is mainly used to sequester metal ions in aqueous solution, and to improve stability.[1][2]
Top medications with this excipient
- Acitretin 25 mg
- Bromocriptine Mesylate 2.5 mg
- Clarinex-D 24 Hour 5 mg / 240 mg
- ConRx Sinus acetaminophen 325 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg
- Contrave bupropion hydrochloride 90 mg / naltrexone hydrochloride 8 mg
- Isotretinoin 10 mg
- Isotretinoin 20 mg
- Montelukast Sodium 10 mg (base)
- Myorisan 30 mg
- Myorisan 40 mg
- Priftin 150 mg
- Promethazine HCl 12.5 mg
- Promethazine Hydrochloride 25 mg
- Risedronate Sodium Delayed-Release 35 mg
- Temazepam 22.5 mg
- Temazepam 15 mg
- Temazepam 30 mg
- Tretinoin 10 mg
- Xartemis XR 325 mg / 7.5 mg
- Zenatane 10 mg
References
- [1]Lanigan RS, Yamarik TA. Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. Int J Toxicol. 2002;21 Suppl 2:95-142. http://www.ncbi.nlm.nih.gov/pubmed/12396676
- [2]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
Further information
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