Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on July 9, 2020.
What is it?
Edetate calcium disodium ([CH2N(CH2CO2H)2]2, also known as calcium EDTA or edetate disodium) is a chelating agent, and is capable of removing a heavy metal, such as lead or mercury, from the blood circulatory system. Edetate calcium disodium is used to treat lead poisoning. These agents also function as chelating agents in cosmetic formulations. Clinical tests reported no absorption of an EDTA salt through the skin, and the Cosmetic Ingredient Review Expert Panel found that these ingredients are safe as used in cosmetic formulations. In industry, EDTA is mainly used to sequester metal ions in aqueous solution, and to improve stability.
Top Medications with this excipient
- Acitretin 10 mg
- Bromocriptine Mesylate 2.5 mg
- Claravis 30 mg
- ConRx Sinus acetaminophen 325 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg
- Enjuvia synthetic B, 1.25 mg
- Enjuvia synthetic B, 0.45 mg
- Enjuvia synthetic B, 0.625 mg
- Enjuvia synthetic B, 0.9 mg
- Isotretinoin 30 mg
- Isotretinoin 20 mg
- Isotretinoin 10 mg
- Midol Complete acetaminophen 500 mg / caffeine 60 mg / pyrilamine maleate 15 mg
- Montelukast Sodium (Chewable) 5 mg (base)
- Myorisan 20 mg
- Nardil 15 mg
- Promethazine Hydrochloride 25 mg
- Tretinoin 10 mg
- Tretinoin 10 mg
- Zenatane 20 mg
- Zenatane 10 mg
 Lanigan RS, Yamarik TA. Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. Int J Toxicol. 2002;21 Suppl 2:95-142. http://www.ncbi.nlm.nih.gov/pubmed/12396676
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
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