Citric Acid Monohydrate
Excipient (pharmacologically inactive substance)
What is it?
Citric acid is a weak organic acid commonly used in the food, cosmetic and pharmaceutical industry. The parent base of citric acid, citrate, is a component of the Krebs cycle, and occurs naturally during metabolism in all living organisms. It is found naturally in citrus fruit such as lemons and limes and is used as a natural preservative. Monohydrate citric acid has one water molecule as part of it's chemical formula, and exists as a white powder.[1][2]
Citrate or citric acid is often used to adjust pH, to add sour flavor to foods and beverages, and to form the salt derivative of minerals and metals for pharmaceuticals, as in the case of potassium citrate, a dietary supplement. According to the FDA Select Committee on Generally Recognized as Safe (GRAS) food substances, citrate salts, including citric acid, are generally regarded as safe when used in normal quantities.[2]
[1] Anastassiadis S, Morgunov IG, Kamzolova SV, et al. Citric acid production patent review. Recent Patent Biotechnol. 2008;2:107-23. http://www.ncbi.nlm.nih.gov/pubmed/19075859
[2] FDA’s SCOGS database; triethyl citrate; SCOGS-Report Number: 84; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=356 Accessed March 26, 2012.
Top Medications with this excipient
- Corvite Fe Multiple Vitamins with Folic Acid and Iron
- Duract Max Strength Cough dextromethorphan hydrobromide 30mg
- FazaClo 200 mg
- Fentora 200 mcg
- FerraPlus 90 vitamin B complex with C, folic acid, iron and docusate
- Folgard vitamin D3 2000 IU / folic acid 800 mcg / vitamin B6 12 mg / vitamin B12 120 mcg
- Juvisync simvastatin 40 mg / sitagliptin 100 mg
- Multivitamin with Fluoride (Chewable) multivitamin with fluoride 1 mg
- Opana ER 20 mg
- Opana ER 40 mg
- Opana ER 7.5 mg
- Opana ER 10 mg
- Ponstel 250 mg
- Ropinirole Hydrochloride 4 mg
- Simvastatin 80 mg
- Simvastatin 40 mg
- Sodium Fluoride (Chewable) 2.2 mg (equiv. fluoride 1 mg)
- Tranylcypromine Sulfate 10 mg
- Vytorin 10 mg / 80 mg
- Ziprasidone Hydrochloride 40 mg
