Citric Acid Monohydrate
Excipient (pharmacologically inactive substance)
What is it?
Citric acid is a weak organic acid commonly used in the food, cosmetic and pharmaceutical industry. The parent base of citric acid, citrate, is a component of the Krebs cycle, and occurs naturally during metabolism in all living organisms. It is found naturally in citrus fruit such as lemons and limes and is used as a natural preservative. Monohydrate citric acid has one water molecule as part of it's chemical formula, and exists as a white powder.[1][2]
Citrate or citric acid is often used to adjust pH, to add sour flavor to foods and beverages, and to form the salt derivative of minerals and metals for pharmaceuticals, as in the case of potassium citrate, a dietary supplement. According to the FDA Select Committee on Generally Recognized as Safe (GRAS) food substances, citrate salts, including citric acid, are generally regarded as safe when used in normal quantities.[2]
[1] Anastassiadis S, Morgunov IG, Kamzolova SV, et al. Citric acid production patent review. Recent Patent Biotechnol. 2008;2:107-23. http://www.ncbi.nlm.nih.gov/pubmed/19075859
[2] FDA’s SCOGS database; triethyl citrate; SCOGS-Report Number: 84; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=356 Accessed March 26, 2012.
Top Medications with this excipient
- Clozapine (Orally Disintegrating) 12.5 mg ()
- Complete-RF prenatal multivitamins with folic acid 1 mg ()
- Duract Max Strength Cough dextromethorphan hydrobromide 30mg ()
- EnLyte vitamin B complex with C, folic acid and iron ()
- Hydrea 500 mg ()
- Hydrochlorothiazide and Triamterene 25 mg / 37.5 mg ()
- Juvisync simvastatin 20 mg / sitagliptin 50 mg ()
- Nadolol 20 mg ()
- Nadolol 80 mg ()
- Opana ER 10 mg ()
- Opana ER 20 mg ()
- Opana ER 40 mg ()
- Ropinirole Hydrochloride 5 mg ()
- Selegiline Hydrochloride 5 mg ()
- Simvastatin 10 mg ()
- Simvastatin 40 mg ()
- Simvastatin 10 mg ()
- Simvastatin 40 mg ()
- Simvastatin 80 mg ()
- Zelapar 1.25 mg ()
