Citric Acid Monohydrate
Excipient (pharmacologically inactive substance)
What is it?
Citric acid is a weak organic acid commonly used in the food, cosmetic and pharmaceutical industry. The parent base of citric acid, citrate, is a component of the Krebs cycle, and occurs naturally during metabolism in all living organisms. It is found naturally in citrus fruit such as lemons and limes and is used as a natural preservative. Monohydrate citric acid has one water molecule as part of it's chemical formula, and exists as a white powder.[1][2]
Citrate or citric acid is often used to adjust pH, to add sour flavor to foods and beverages, and to form the salt derivative of minerals and metals for pharmaceuticals, as in the case of potassium citrate, a dietary supplement. According to the FDA Select Committee on Generally Recognized as Safe (GRAS) food substances, citrate salts, including citric acid, are generally regarded as safe when used in normal quantities.[2]
[1] Anastassiadis S, Morgunov IG, Kamzolova SV, et al. Citric acid production patent review. Recent Patent Biotechnol. 2008;2:107-23. http://www.ncbi.nlm.nih.gov/pubmed/19075859
[2] FDA’s SCOGS database; triethyl citrate; SCOGS-Report Number: 84; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=356 Accessed March 26, 2012.
Top Medications with this excipient
- Hydrochlorothiazide and Triamterene 25 mg / 37.5 mg (Sandoz Pharmaceuticals Inc.)
- Opana ER 40 mg (Endo Pharmaceuticals Inc.)
- Opana ER 20 mg (Endo Pharmaceuticals Inc.)
- Opana ER 10 mg (Endo Pharmaceuticals Inc.)
- Opana ER 30 mg (Endo Pharmaceuticals Inc.)
- Opana ER 15 mg (Endo Pharmaceuticals Inc.)
- Opana ER 5 mg (Endo Pharmaceuticals Inc.)
- Simvastatin 20 mg (Aurobindo Pharma)
- Simvastatin 20 mg (Lupin Pharmaceuticals, Inc)
- Simvastatin 20 mg (Teva Pharmaceuticals USA)
- Simvastatin 40 mg (Lupin Pharmaceuticals, Inc)
- Simvastatin 40 mg (Aurobindo Pharma)
- Simvastatin 40 mg (Teva Pharmaceuticals USA)
- Simvastatin 10 mg (Lupin Pharmaceuticals, Inc)
- Simvastatin 20 mg (Accord Healthcare)
- Simvastatin 10 mg (Aurobindo Pharma)
- Suboxone 8 mg / 2 mg (Reckitt Benckiser Pharmaceuticals, Inc.)
- Vytorin 10 mg / 40 mg (Merck & Company Inc.)
- Vytorin 10 mg / 20 mg (Merck & Company Inc.)
- Zelapar 1.25 mg (Valeant Pharmaceuticals Inc.)
