Citric Acid Monohydrate
Excipient (pharmacologically inactive substance)
What is it?
Citric acid is a weak organic acid commonly used in the food, cosmetic and pharmaceutical industry. The parent base of citric acid, citrate, is a component of the Krebs cycle, and occurs naturally during metabolism in all living organisms. It is found naturally in citrus fruit such as lemons and limes and is used as a natural preservative. Monohydrate citric acid has one water molecule as part of it's chemical formula, and exists as a white powder.[1][2]
Citrate or citric acid is often used to adjust pH, to add sour flavor to foods and beverages, and to form the salt derivative of minerals and metals for pharmaceuticals, as in the case of potassium citrate, a dietary supplement. According to the FDA Select Committee on Generally Recognized as Safe (GRAS) food substances, citrate salts, including citric acid, are generally regarded as safe when used in normal quantities.[2]
[1] Anastassiadis S, Morgunov IG, Kamzolova SV, et al. Citric acid production patent review. Recent Patent Biotechnol. 2008;2:107-23. http://www.ncbi.nlm.nih.gov/pubmed/19075859
[2] FDA’s SCOGS database; triethyl citrate; SCOGS-Report Number: 84; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=356 Accessed March 26, 2012.
Top Medications with this excipient
- Carbamazepine Extended-Release 300 mg (Prasco Laboratories)
- Carbamazepine Extended-Release 200 mg (Prasco Laboratories)
- Carbamazepine Extended-Release 100 mg (Prasco Laboratories)
- Carbatrol 300 mg (Shire US Inc.)
- Carbatrol 100 mg (Shire US Inc.)
- Droxia 300 mg (Bristol-Myers Squibb)
- DROXIA 400 MG (Bristol-Myers Squibb)
- Hydrea 500 mg (Bristol-Myers Squibb)
- Hydrochlorothiazide and Triamterene 25 mg / 37.5 mg (Sandoz Pharmaceuticals Inc.)
- Opana ER 10 mg (Endo Pharmaceuticals Inc.)
- Opana ER 20 mg (Endo Pharmaceuticals Inc.)
- Opana ER 40 mg (Endo Pharmaceuticals Inc.)
- Ponstel 250 mg (Shionogi Inc.)
- Potassium Chloride Extended-Release 8 mEq (600 mg) (Paddock Laboratories, Inc.)
- Potassium Chloride Extended-Release 10 mEq (750 mg) (Paddock Laboratories, Inc.)
- Se-Natal One prenatal multivitamins with folic acid 1 mg (Seton Pharmaceuticals)
- Selegiline Hydrochloride 5 mg (Stada Pharmaceuticals Inc)
- Ziprasidone Hydrochloride 60 mg (Sandoz Inc.)
- Ziprasidone Hydrochloride 20 mg (Sandoz Inc.)
- Ziprasidone Hydrochloride 80 mg (Sandoz Inc.)
