Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on July 17, 2020.
What is it?
Carboxymethylcellulose appears as white, fibrous, free-flowing powder, and is used commonly as an FDA-approved disintegrant in pharmaceutical manufacturing. Disintegrants facilitate the breakup of a tablet in the intestinal tract after oral administration. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness. Carboxymethylcellulose is available in different salt forms, such as sodium or calcium.
Polymers of carboxymethylcellulose sodium are also the active ingredient in many over-the-counter dry-eye or "natural tears" products, such as Refresh Tears or TheraTears Lubricant Eye Drops.
According to the FDA Select Committee on GRAS food Substances, carboxymethylcellulose sodium is virtually unabsorbed. Carboxymethylcellulose sodium is generally regarded as safe when used in normal quantities.
Top Medications with this excipient
- Flucytosine 500 mg
- Nalfon fenoprofen calcium 200 mg
- Nitrofurantoin (Monohydrate/Macrocrystals) 100 mg
- Pletal 50 mg
- Pletal 100 mg
- Triglide 160 mg
- Ziprasidone Hydrochloride 60 mg
- Ziprasidone Hydrochloride 80 mg
- Ziprasidone Hydrochloride 20 mg
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
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