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Reye syndrome

Medically reviewed by Drugs.com. Last updated on Jun 23, 2023.

What is Reye syndrome?

Harvard Health Publishing

Reye syndrome is a very rare disorder that damages many parts of the body, especially the brain and the liver. For unknown reasons, the parts of the cells that make energy (mitochondria) stop working correctly, which causes severe illness. The most serious problems are swelling of the brain and problems with the breakdown of fat, which results in buildup in the liver and other organs. The illness can be fatal, especially if not detected early and treated appropriately.

Although Reye syndrome can occur at any age, it most often affects children between the ages of 3 and 12.

Reye syndrome typically occurs several days after the child is recovering from a viral infection, such as the flu, common cold, or chickenpox. It also can develop while the child is still sick, a few days after the viral illness began. While the exact cause of Reye syndrome is not known, researchers believe that it may be due to an abnormal response to aspirin or aspirin-containing products taken during a viral illness. For this reason, never give aspirin or aspirin-containing medicines to children with fever or a flu-like illness.

Symptoms

Symptoms can include

In infants, the symptoms of Reye syndrome may not follow this typical pattern. For example, infants with Reye syndrome do not always vomit.

Diagnosis

The doctor may suspect a child has Reye syndrome based on the symptoms and a history of very recent viral illness. Blood tests, including tests of liver function, will be done. Imaging tests such as ultrasound and CT scans usually show steatosis (fatty infiltration) of the liver and other organs. Other tests may be necessary to confirm the diagnosis, including:

Reye syndrome can be difficult to diagnose. It is sometimes mistaken for other serious illnesses, such as encephalitis, meningitis, uncontrolled diabetes, or drug overdose.

Expected duration

How long it takes to recover from Reye syndrome depends on how much the brain has swelled. People with mild disease usually recover quickly and completely.

Prevention

Although a clear link between aspirin and Reye syndrome has not yet been proven, experts agree that to prevent Reye syndrome, the safest approach is never to give aspirin or aspirin-containing medicines to children unless specifically recommended by the child's doctor. Read labels carefully. Look for the word aspirin and other words that also mean aspirin: acetylsalicylate, acetylsalicylic acid, salicylic acid and salicylate. When necessary, non-aspirin medicines, such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin), should be used instead.

Treatment

Treatment depends on the symptoms, but all patients with Reye syndrome need to be treated in a hospital and monitored closely. Treatment focuses on protecting the brain against irreversible damage by preventing or reducing brain swelling.

Specific treatments may include

When to call a professional

Reye syndrome is a serious, life-threatening condition. If your child has had a viral infection and has any symptoms of Reye syndrome, call your doctor immediately. It is an emergency!

Prognosis

With early diagnosis and treatment, the chances of recovery are usually excellent. Some people will recover fully, while others may have permanent brain damage. The outlook is poorer for people with Reye syndrome who rapidly become unconscious. If diagnosis and treatment are delayed, the chances of successful recovery and survival are less.

Additional info

American Academy of Pediatrics (AAP)
https://www.aap.org/

Centers for Disease Control and Prevention (CDC)
https://www.cdc.gov/

National Reye's Syndrome Foundation
https://www.reyessyndrome.org/


Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.