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Pentacarinat and Alcohol/Food Interactions

There is 1 alcohol/food/lifestyle interaction with Pentacarinat (pentamidine).

Major

Pentamidine High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Major Potential Hazard, Moderate plausibility

pentamidine - pancreatitis

Acute and potentially fatal pancreatitis has been reported with parenteral use and, rarely, oral inhalation of pentamidine. Patients with a history of or known risk factors for pancreatitis, such as alcohol abuse or hypertriglyceridemia, should be monitored closely during therapy with pentamidine. Therapy should be discontinued at the first signs or symptoms suggestive of pancreatitis (e.g., nausea, vomiting, abdominal pain, hyperamylasemia with dysglycemia, rising triglycerides, decreasing serum calcium), and preferably permanently discontinued if clinical pancreatitis develops.

References

  1. Schwartz MS, Cappell MS (1989) "Pentamidine-associated pancreatitis." Dig Dis Sci, 34, p. 1617-20
  2. Wood G, Wetzig N, Hogan P, Whitby M (1991) "Survival from pentamidine induced pancreatitis and diabetes mellitus." Aust N Z J Med, 21, p. 341-2
  3. Klatt EC (1992) "Pathology of pentamidine-induced pancreatitis." Arch Pathol Lab Med, 116, p. 162-4
  4. "Product Information. Nebupent (pentamidine)." Fujisawa
  5. (2001) "Product Information. Pentam 300 (pentamidine)." Fujisawa
  6. Tocci G, Alba L, D'Amato C, Grisetti S, Sampaolesi A, Visco GL (1993) "Pancreatitis associated with aerosolized pentamidine." Int Conf AIDS, 9, p. 505
  7. Sauleda J, Gea JG, Aguar MC, Aran X, Pasto M, Broquetas JM (1994) "Probable pentamidine-induced acute pancreatitis." Ann Pharmacother, 28, p. 52-3
View all 7 references

Pentacarinat drug interactions

There are 374 drug interactions with Pentacarinat (pentamidine).

Pentacarinat disease interactions

There are 10 disease interactions with Pentacarinat (pentamidine) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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