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Vitamin K (Phytonadione) Injection Shortage

Last Updated: July 5, 2018
Status: Resolved

Reason for the Shortage
    • Pfizer had vitamin K injection on market reserve due to increased demand. The increased demand is thought to be due to increased use of synthetic inhaled cannabinoids laced with anticoagulants.
    • Oral vitamin K is not affected by this shortage.
Available Products
    • Vitamin K injection, Amphastar, 2 mg/mL, 0.5 mL SAF-T-JET prefilled syringe, 10 count, NDC 76329-1240-01
    • Vitamin K injection, Pfizer, 10 mg/mL, 1 mL ampule, 25 count, NDC 00409-9158-01
    • Vitamin K injection, Pfizer, 2 mg/mL, 0.5 mL ampule, 25 count, NDC 00409-9157-01

Estimated Resupply Dates

    • Pfizer has vitamin K injection in 1 mg/mL 0.5 mL ampules and 10 mg/mL 1 mL ampules available.


    • Avoid off-label oral administration of injectable Vitamin K during the shortage.
    • Vitamin K from Amphastar contains polysorbate 80 and propylene glycol.
    • Vitamin K from Hospira contains benzyl alcohol. The product labeling states there is no evidence to suggest toxicity of benzyl alcohol if used as recommended.


Updated July 5, 2018 by Michelle Wheeler, PharmD, Drug Information Specialist. Created June 29, 2015 by Michelle Wheeler, PharmD, Drug Information Specialist. Copyright 2018, Drug Information Service, University of Utah, Salt Lake City, UT.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.