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Drug Interactions between UriSym and varicella virus vaccine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

phenyl salicylate varicella virus vaccine

Applies to: UriSym (hyoscyamine / methenamine / methylene blue / phenyl salicylate) and varicella virus vaccine

GENERALLY AVOID: In pediatric patients, use of varicella virus vaccine during salicylate or salicylate-containing therapy may pose a theoretical risk of Reye's syndrome based on known association of the syndrome with salicylates and natural varicella infection. Children and adolescents receiving the vaccine in U.S. clinical studies were instructed not to use salicylates for six weeks after vaccination. There were no reports of Reye's syndrome during these studies.

MANAGEMENT: Vaccine recipients less than 18 years of age should avoid the use of salicylates for six weeks after immunization with varicella virus vaccine.

References

  1. (2001) "Product Information. Dipentum (olsalazine)." Meda Pharmaceuticals
  2. (2022) "Product Information. Varivax (varicella virus vaccine)." Merck & Co., Inc

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Drug and food interactions

Moderate

hyoscyamine food

Applies to: UriSym (hyoscyamine / methenamine / methylene blue / phenyl salicylate)

GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.

MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.

References

  1. Linnoila M (1973) "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol, 6, p. 107-12

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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