Drug Interactions between tyrosine and Urolene Blue

GENERALLY AVOID: Coadministration of L-tyrosine with monoamine oxidase inhibitors (MAOIs) may increase the risk of severe hypertensive reactions. Tyrosine is a nonessential amino acid that is a precursor of thyroxine, melanin, and the neurotransmitters dopamine and norepinephrine. Concomitant use with MAOIs may therefore lead to increased levels of these catecholamines and their associated adverse effects. However, clinical data are not available for nonselective or selective MAOIs.

MANAGEMENT: In general, tyrosine should not be used concurrently with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). Some authorities consider the combination of phenelzine with L-tyrosine to be contraindicated. If concomitant use is required, patients should be advised to promptly seek medical attention if they experience potential signs and symptoms of a hypertensive crisis such as severe headache, visual disturbances, difficulty thinking, stupor or coma, seizures, chest pain, unexplained nausea or vomiting, and stroke-like symptoms.