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Drug Interactions between Trasylol and tretinoin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

aprotinin tretinoin

Applies to: Trasylol (aprotinin) and tretinoin

MONITOR CLOSELY: Coadministration of tretinoin (all-trans retinoic acid) with antifibrinolytic agents may increase the risk of thrombosis. Tretinoin is associated with a risk of both venous and arterial thrombosis during the first month of treatment that may involve any organ system. Cases of fatal thrombotic complications have been reported rarely in patients concomitantly treated with tretinoin and antifibrinolytic agents.

MANAGEMENT: Caution is advised when tretinoin is prescribed in combination with antifibrinolytic agents such as aminocaproic acid, aprotinin, or tranexamic acid. Patients should be advised to seek medical attention immediately if they experience potential signs and symptoms of blood clots such as chest pain, shortness of breath, hemoptysis, hematuria, sudden loss of vision, and pain, redness or swelling in an extremity.

References

  1. (2001) "Product Information. Vesanoid (tretinoin)." Roche Laboratories
  2. (2022) "Product Information. Lysteda (tranexamic acid)." Xanodyne Pharmaceuticals Inc
  3. Hashimoto S, Koike T, Tatewaki W, et al. (1994) "Fatal thromboembolism in acute promyelocytic leukemia during all-trans retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage." Leukemia, 8, p. 1113-5

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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