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Drug Interactions between Toposar and vincristine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

etoposide vinCRIStine

Applies to: Toposar (etoposide) and vincristine

Concurrent administration of vincristine and etoposide may lead to an earlier onset and/or an increased severity of side effects. The mechanism is inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If vincristine and etoposide are used concomitantly, caution and close observation are advised.

References

  1. Zhou-Pan XR, Seree E, Zhou XJ, et al. (1993) "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res, 53, p. 5121-6
  2. (2001) "Product Information. Oncovin (vincristine)." Lilly, Eli and Company

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Mitotic inhibitors

Therapeutic duplication

The recommended maximum number of medicines in the 'mitotic inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'mitotic inhibitors' category:

  • Toposar (etoposide)
  • vincristine

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer