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Can you take Tecovirimat with Tucatinib?

1 drug interaction and 5 additional warnings found for the following 2 drugs:

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Drug interactions

Moderate drug interactions

Moderate:

tucatinib tecovirimat

Applies to: tucatinib and tecovirimat

Tecovirimat may increase the blood levels of tucatinib.

This may increase the risk of serious side effects such as:

  • liver injury
  • diarrhea
  • nausea
  • vomiting
  • abdominal pain
  • seizures

Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

Moderate food/lifestyle interactions

Moderate:

tecovirimat Food/Lifestyle

Applies to: tecovirimat

Food may increase the absorption of tecovirimat when taken orally, which may lead to higher blood levels of the medication.

You should take oral preparations of tecovirimat within 30 minutes after a full meal containing moderate or high fat (approximately 600 calories and 25 g of fat) with 6 to 8 ounces of water.

Disease interactions

4 potential interactions Applies to: 4 conditions, including Hyperkalemia, Liver Disease, Renal Dysfunction, and Smallpox.

Hyperkalemia

Moderate:

tucatinib

Tucatinib has a moderate potential interaction with Hyperkalemia.

Tucatinib contains 60.6 mg potassium per 300 mg dose. This should be taken into consideration especially in patients with hyperkalemia or impaired kidney function who are on a controlled potassium diet.

Liver Disease

Moderate:

tucatinib

Tucatinib has a moderate potential interaction with Liver Disease.

Tucatinib is a hepatotoxic drug. Additionally, its exposure is increased in patients with severe hepatic impairment. This is the reason why the dosage must be reduced in these patients (Child-Pugh C). Consult the manufacturers prescribing information for details on dosage modification.

Renal Dysfunction

Moderate:

tucatinib

Tucatinib has a moderate potential interaction with Renal Dysfunction.

Tucatinib contains 60.6 mg potassium per 300 mg dose. This should be taken into consideration especially in patients with hyperkalemia or impaired kidney function who are on a controlled potassium diet.

Smallpox

Major:

tecovirimat

Tecovirimat has a major potential interaction with Smallpox.

Tecovirimat injection is contraindicated in patients with severe renal dysfunction (CrCl below 30 mL/min).

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More resources

tecovirimat

A total of 537 drugs are known to interact with tecovirimat.

tucatinib

A total of 549 drugs are known to interact with tucatinib.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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