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Drug Interactions between Tecfidera and Vitamin B12

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between Tecfidera and Vitamin B12. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Tecfidera

A total of 639 drugs are known to interact with Tecfidera.

Vitamin B12

A total of 15 drugs are known to interact with Vitamin B12.

Drug and food interactions

Minor

dimethyl fumarate food

Applies to: Tecfidera (dimethyl fumarate)

Food does not significantly affect the oral bioavailability of dimethyl fumarate. Administration of dimethyl fumarate with a high-fat, high-calorie meal did not affect the systemic exposure (AUC) to its active metabolite, monomethyl fumarate (MMF), but decreased its peak plasma concentration (Cmax) by 40% and prolonged the time to reach peak concentration (Tmax) from 2.0 hours to 5.5 hours. In the study, the incidence of flushing was reduced by approximately 25% in the fed state. Dimethyl fumarate may be taken with or without food; however, taking it with food may help reduce flushing.

References (1)
  1. (2013) "Product Information. Tecfidera (dimethyl fumarate)." Biogen

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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