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Drug Interactions between Tamiflu and Xofluza

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between Tamiflu and Xofluza. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Tamiflu

A total of 9 drugs are known to interact with Tamiflu.

Xofluza

A total of 53 drugs are known to interact with Xofluza.

Drug and food interactions

Moderate

baloxavir marboxil food

Applies to: Xofluza (baloxavir marboxil)

GENERALLY AVOID: Coadministration with foods or medications that contain polyvalent cations such as dairy products, calcium-fortified beverages, certain laxatives, antacids, or oral supplements may decrease the plasma concentrations and therapeutic efficacy of baloxavir. The proposed mechanism is chelation of baloxavir by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. A significant decrease in baloxavir exposure was observed in monkeys when the prodrug, baloxavir marboxil, was coadministered with calcium, aluminum, magnesium, or iron. However, clinical data in humans are lacking.

When baloxavir marboxil was administered with food, baloxavir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 48% and 36%, respectively, relative to administration under fasting. These changes are not considered clinically significant.

MANAGEMENT: Baloxavir marboxil may be taken with or without food. However, coadministration with dairy products, calcium-fortified beverages, or polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., calcium, iron, magnesium, selenium, or zinc) should be avoided.

References (2)
  1. Cerner Multum, Inc. "Australian Product Information."
  2. (2018) "Product Information. Xofluza (baloxavir marboxil)." Genentech

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Anti-influenza drugs

Therapeutic duplication

The recommended maximum number of medicines in the 'anti-influenza drugs' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'anti-influenza drugs' category:

  • Tamiflu (oseltamivir)
  • Xofluza (baloxavir marboxil)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer