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Drug Interactions between tacrine and viloxazine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

tacrine viloxazine

Applies to: tacrine and viloxazine

GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 1A2 may significantly increase the plasma concentrations of tacrine, which has been shown to be primarily metabolized by the isoenzyme.

MANAGEMENT: Concomitant use of tacrine with potent CYP450 1A2 inhibitors should generally be avoided. If coadministration is necessary, monitor for side effects, such as nausea, vomiting, sweating, and diarrhea. The risk of hepatotoxicity may be increased.

References (2)
  1. Becquemont L, Ragueneau I, LeBot MA, Riche C, FunckBrentano C, Jaillon P (1997) "Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans." Clin Pharmacol Ther, 61, p. 619-27
  2. (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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