Drug Interactions between strontium-89 chloride and Xalkori
This report displays the potential drug interactions for the following 2 drugs:
- strontium-89 chloride
- Xalkori (crizotinib)
Interactions between your drugs
strontium-89 chloride crizotinib
Applies to: strontium-89 chloride and Xalkori (crizotinib)
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: The concomitant use of bone marrow depressants or cytotoxic agents with strontium-89 chloride may result in additive myelosuppression. Bone marrow toxicity is expected following the administration of strontium-89 chloride alone, especially with regards to white blood cells (WBCs) and platelets. The nadir of platelet depression for most patients is about 4 to 16 weeks after a strontium-89 chloride injection. Recovery can be slow and may not be complete.
MANAGEMENT: Concomitant use of strontium-89 chloride and a bone marrow suppressant or cytotoxic agent is not generally recommended. Some authorities advise separating strontium-89 chloride administration from that of a cytotoxic agent by an interval of at least 12 weeks, provided that the patient's hematological parameters are stable and within the normal range. The product labeling for the concomitant myelosuppressive/cytotoxic medication should be consulted for more specific recommendations. Patients should be advised to contact their physician if they develop signs and symptoms of myelosuppression such as pallor, dizziness, fatigue, lethargy, fainting, easy bruising or bleeding, or signs of infection such as fever, chills, sore throat, body aches, and other influenza-like symptoms.
References
- "Multum Information Services, Inc. Expert Review Panel"
- "Product Information. Metastron (strontium (89Sr) chloride)." GE Healthcare Australia Pty Ltd (2014):
- GE Healthcare Canada Inc. "Product monograph metastron strontium [89Sr] chloride https://pdf.hres.ca/dpd_pm/00020852.PDF" (2023):
- Isotherapeutics Group LLC "Strontium chloride SR-89- strontium chloride sr-89 injection https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=c89bcf16-399d-48e0-a4e3-849261aaa310&type=display" (2023):
Drug and food interactions
crizotinib food
Applies to: Xalkori (crizotinib)
Do not consume grapefruit or grapefruit juice during treatment with crizotinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of crizotinib to dangerous levels and cause an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with crizotinib. You may take crizotinib with or without food, but take it the same time each day. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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