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Can you take Sonrotoclax with Zinca-pak?

1 drug interaction and 3 additional warnings found for the following 2 drugs:

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Drug interactions

Minor drug interactions

Minor:

zinc sulfate sonrotoclax

Applies to: Zinca-pak (zinc sulfate) and sonrotoclax

Information for this minor interaction is available on the professional version.

Food/lifestyle interactions

Major food/lifestyle interactions

Major:

sonrotoclax Food/Lifestyle

Applies to: sonrotoclax

Food may increase the blood levels of sonrotoclax. You should take each dose of sonrotoclax with a meal and glass of water at approximately the same time every day to maintain consistent blood levels and effects. Avoid consuming grapefruit, grapefruit juice, grapefruit hybrids, star fruit, or Seville oranges (also known as bitter or sour oranges) during treatment, as it may increase blood levels of sonrotoclax to undesirable levels. This may increase your risk of developing tumor lysis syndrome, a serious and potentially life-threatening condition that is caused by the rapid breakdown of cancer cells that can lead to kidney failure and even death. Symptoms of tumor lysis syndrome include fever, chills, nausea, vomiting, confusion, shortness of breath, seizure, irregular heartbeat, decreased urination, unusual tiredness, and muscle cramps or twitches. You should seek immediate medical attention if you develop any of these symptoms. The risk and/or severity of other side effects may also increase, including nausea, vomiting, diarrhea, fatigue, and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. Contact your doctor immediately if you develop signs of infection such as fever, chills, cough, sore throat, shortness of breath, diarrhea, blood in phlegm, weight loss, red or inflamed skin, skin sores, or painful urination. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Disease interactions

2 potential interactions Applies to: 2 conditions, including Malabsorption Syndrome and Renal Dysfunction.

Malabsorption Syndrome

Moderate:

Zinca-pak

The zinc sulfate in Zinca-pak has a moderate potential interaction with Malabsorption Syndrome.

The trace metals manganese, chromium, copper, selenium, and zinc are absorbed in the GI tract from dietary sources and following administration of oral supplements. GI absorption may be decreased in patients with malabsorption syndromes. Therefore, larger dosages may be required when these supplements are given orally. Parenteral administration may be appropriate.

Renal Dysfunction

Moderate:

Zinca-pak

The zinc sulfate in Zinca-pak has a moderate potential interaction with Renal Dysfunction.

The trace metals, chromium and zinc, are excreted primarily in the urine. Selenium is partially excreted in the urine. Supplemental doses of these agents may need to be adjusted, reduced, or omitted in patients with renal dysfunction.

More resources

sonrotoclax

A total of 306 drugs are known to interact with sonrotoclax.

Zinca-pak

A total of 165 drugs are known to interact with Zinca-pak.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.