Drug interactions between sonidegib and vismodegib
Interactions between your drugs
- Sonidegib is in the drug class hedgehog pathway inhibitors.
- Sonidegib is used to treat Basal Cell Carcinoma.
- Vismodegib is a member of the drug class hedgehog pathway inhibitors.
- Vismodegib is used to treat Basal Cell Carcinoma.
Drug and food interactions
Applies to: sonidegib
Sonidegib should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. The presence of food can significantly increase the absorption of sonidegib into the blood stream. This may increase side effects such as muscle spasms, muscle pain, muscle weakness, fatigue, nausea, vomiting, diarrhea, loss of appetite, weight loss, hair loss, itching, and taste abnormalities. You may also have an increased risk of developing a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment with sonidegib, especially if these symptoms are accompanied by fever or dark colored urine. Grapefruit juice may also increase the blood levels of sonidegib and should be avoided. Talk to your doctor or pharmacist if you have any questions or concerns.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Hedgehog pathway inhibitors
The recommended maximum number of medicines in the 'hedgehog pathway inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'hedgehog pathway inhibitors' category:
Drug Interaction Classification
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Do not stop taking any medications without consulting your healthcare provider.