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Drug Interactions between sofosbuvir / velpatasvir and topotecan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

topotecan velpatasvir

Applies to: topotecan and sofosbuvir / velpatasvir

GENERALLY AVOID: Coadministration with velpatasvir may increase the plasma concentrations of topotecan. Although not studied, a clinically significant pharmacokinetic interaction may be anticipated because topotecan is a substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), and velpatasvir inhibits both of these drug transporters according to the manufacturer.

MANAGEMENT: Concomitant use of topotecan with sofosbuvir-velpatasvir is not recommended.

References (1)
  1. (2016) "Product Information. Epclusa (sofosbuvir-velpatasvir)." Gilead Sciences

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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