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Drug Interactions between sofosbuvir / velpatasvir and tenofovir disoproxil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

tenofovir velpatasvir

Applies to: tenofovir disoproxil and sofosbuvir / velpatasvir

MONITOR: Coadministration of tenofovir disoproxil fumarate with velpatasvir may increase the plasma concentrations of tenofovir. The proposed mechanism is inhibition of the P-glycoprotein (P-gp) transporter-mediated efflux of tenofovir DF by velpatasvir. In pharmacokinetic studies, administration of various tenofovir DF-containing products or antiretroviral regimens in combination with sofosbuvir-velpatasvir 400 mg-100 mg once daily to healthy volunteers resulted in approximately 1.3- to 1.8-fold increases in tenofovir systemic exposure (AUC). In contrast, no significant interaction was observed with tenofovir alafenamide.

MANAGEMENT: Caution is advised when tenofovir disoproxil fumarate is prescribed with sofosbuvir-velpatasvir. Renal function should be closely monitored.

References (2)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. (2016) "Product Information. Epclusa (sofosbuvir-velpatasvir)." Gilead Sciences

Drug and food interactions

Minor

tenofovir food

Applies to: tenofovir disoproxil

Food enhances the oral absorption and bioavailability of tenofovir, the active entity of tenofovir disoproxil fumarate. According to the product labeling, administration of the drug following a high-fat meal increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of tenofovir by approximately 14% and 40%, respectively, compared to administration in the fasting state. However, administration with a light meal did not significantly affect the pharmacokinetics of tenofovir compared to administration in the fasting state. Food delays the time to reach tenofovir Cmax by approximately 1 hour. Tenofovir disoproxil fumarate may be administered without regard to meals.

References (1)
  1. (2001) "Product Information. Viread (tenofovir)." Gilead Sciences

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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