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Drug Interactions between sodium phosphate p32 and umbralisib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sodium phosphate p32 umbralisib

Applies to: sodium phosphate p32 and umbralisib

MONITOR: The concomitant use of bone marrow depressants and sodium phosphate P-32 may have additive myelosuppressive effects.

MANAGEMENT: Patients should be monitored for excessive bone marrow suppression during treatment with sodium phosphate P-32. Sodium phosphate P-32 should not be used as part of a sequential treatment with a chemotherapeutic agent. Dose reductions of the other bone marrow depressants may be necessary. The manufacturer's labeling should be consulted for more specific recommendations for each agent involved. Patients should be advised to contact their physician if they develop signs and symptoms of myelosuppression such as pallor, dizziness, fatigue, lethargy, fainting, easy bruising or bleeding, or signs of infection such as fever, chills, sore throat, body aches, and other influenza-like symptoms.

References (1)
  1. AnazaoHealth Corporation (2023) P32 sodium phosphate - p32 sodium phosphate solution https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=735f92e3-cc92-4d9b-afe8-f935a685ee78&type=display

Drug and food interactions

Moderate

umbralisib food

Applies to: umbralisib

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of umbralisib. When a single oral dose of umbralisib was administered with a high-fat, high-calorie meal (approximately 917 calories; 171 calories from protein, 232 calories from carbohydrate, 502 calories from fat) in healthy subjects, umbralisib peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 115% and 61%, respectively, compared to administration under fasted conditions.

MANAGEMENT: Umbralisib should be administered with food at approximately the same time each day.

References (1)
  1. "Multum Information Services, Inc. Expert Review Panel"

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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