Drug interactions between Sinemet and Stalevo
Interactions between your drugs
levodopa ↔ entacapone
Applies to:Sinemet (carbidopa/levodopa) and Stalevo (carbidopa/entacapone/levodopa)
Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
For clinical details see professional interaction data.
Drug and food interactions
Applies to: Sinemet (carbidopa / levodopa), Stalevo (carbidopa / entacapone / levodopa)
Alcohol can increase the nervous system side effects of levodopa such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with levodopa. You may experience reduced effectiveness of levodopa in the presence of foods or enteral (tube) feedings with a high protein content. This may make the symptoms of Parkinson's disease worse. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medication. Contact your doctor if your condition changes.
Applies to: Stalevo (carbidopa / entacapone / levodopa)
Alcohol can increase the nervous system side effects of entacapone such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with entacapone. Do not use more than the recommended dose of entacapone, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Dopaminergic agents for parkinsonism
The recommended maximum number of medicines in the 'dopaminergic agents for parkinsonism' category to be taken concurrently is usually one. Your list includes four medicines belonging to the 'dopaminergic agents for parkinsonism' category:
- carbidopa (active ingredient in Sinemet (carbidopa/levodopa))
- levodopa (active ingredient in Sinemet (carbidopa/levodopa))
- carbidopa (active ingredient in Stalevo (carbidopa/entacapone/levodopa))
- levodopa (active ingredient in Stalevo (carbidopa/entacapone/levodopa))
Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.