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Drug Interactions between Seromycin and Vaxchora

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

cycloSERINE cholera vaccine, live

Applies to: Seromycin (cycloserine) and Vaxchora (cholera vaccine, live)

ADJUST DOSING INTERVAL: The use of live, attenuated cholera vaccine with systemic antibiotics may result in a diminished immunologic response to the vaccine. Some antibiotics may be active against the vaccine strain of Vibrio cholerae, thereby preventing a sufficient degree of multiplication to occur in order to induce a protective immune response.

MANAGEMENT: Live, attenuated cholera vaccine should not be administered during or for at least 14 days after treatment with systemic antibiotics.

References

  1. "Product Information. Vaxchora (cholera vaccine, live)." PaxVax (2016):

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Drug and food interactions

Major

cycloSERINE food

Applies to: Seromycin (cycloserine)

GENERALLY AVOID: Coadministration with alcohol may potentiate some of the central nervous system adverse effects of cycloserine and its prodrug, terizidone. These effects may include dizziness, drowsiness, depression, anxiety, psychoses, memory impairment, confusion, and convulsions.

MANAGEMENT: Patients should be advised to avoid the consumption of alcohol during treatment with cycloserine or terizidone. The use of these medications is contraindicated in patients with chronic alcohol consumption or alcoholism.

MONITOR CLOSELY: Coadministration with caffeine may potentiate some of the central nervous system adverse effects of cycloserine and its prodrug, terizidone. These effects may include insomnia, excitability, irritability, anxiety, tremor, psychoses, and convulsions.

MANAGEMENT: Caution is advised when cycloserine or terizidone is used with caffeine. Consumption of certain beverages or stimulants with very high caffeine levels should be avoided as a precautionary measure.

References

  1. "Product Information. Seromycin (cycloserine)." Dura Pharmaceuticals PROD (2001):
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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Moderate

cholera vaccine, live food

Applies to: Vaxchora (cholera vaccine, live)

ADJUST DOSING INTERVAL: There are no data regarding the concurrent administration of cholera oral vaccine with food or beverages.

MANAGEMENT: The manufacturer recommends that patients avoid eating or drinking for 60 minutes before and after administration of cholera oral vaccine.

References

  1. "Product Information. Vaxchora (cholera vaccine, live)." PaxVax (2016):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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