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Drug Interactions between Santyl and Silvadene

This report displays the potential drug interactions for the following 2 drugs:

  • Santyl (collagenase topical)
  • Silvadene (silver sulfadiazine topical)

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Interactions between your drugs


silver sulfADIAZINE topical collagenase topical

Applies to: Silvadene (silver sulfadiazine topical) and Santyl (collagenase topical)

Talk to your doctor before using silver sulfADIAZINE topical together with collagenase topical. Silver sulfADIAZINE topical can reduce the effects of collagenase topical when applied to the same site. Silver sulfADIAZINE topical should generally not be used on wounds treated with collagenase topical unless specifically directed by your doctor. If silver sulfADIAZINE topical has been used, the site should be carefully cleansed by repeated washings with normal saline before application of collagenase topical. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No interactions were found. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.