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Drug Interactions between RotaShield and teplizumab

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

rotavirus vaccine teplizumab

Applies to: RotaShield (rotavirus vaccine) and teplizumab

ADJUST DOSING INTERVAL: The administration of live, attenuated viral or bacterial vaccines or oncolytic immunotherapy containing live, attenuated virus or bacteria to patients receiving teplizumab is not recommended, and may be associated with a risk of disseminated infection due to enhanced replication of virus or bacteria in the presence of diminished immune competence. In addition, teplizumab may interfere with the immune response to vaccination and decrease vaccine efficacy. However, data are not available. A specific timeframe for immunization of infants exposed to teplizumab in utero is not available due to a lack of sufficient data about infant serum levels or the duration of persistence of teplizumab in infant serum after birth.

MANAGEMENT: The administration of live, attenuated viral or bacterial vaccines or oncolytic immunotherapy containing live, attenuated virus or bacteria is not recommended within the 8 weeks prior to treatment, during, and for up to 52 weeks after treatment with teplizumab. Patients should be advised to receive all age-appropriate vaccinations prior to starting treatment with teplizumab. The risks and benefits should be considered prior to the administration of live, attenuated viral or bacterial vaccines or oncolytic immunotherapy containing live, attenuated virus or bacteria to infants exposed to teplizumab in utero.

References

  1. (2022) "Product Information. Tzield (teplizumab)." Provention Bio, Inc.

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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