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Drug Interactions between Rituxan and zilucoplan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

riTUXimab zilucoplan

Applies to: Rituxan (rituximab) and zilucoplan

Consumer information for this interaction is not currently available.

MONITOR: Theoretically, the complement inhibitors eculizumab, ravulizumab, and zilucopan may reduce the complement-dependent pharmacodynamic effects of rituximab. The proposed mechanism is related to the potential inhibitory effect of complement inhibitors on complement-dependent cytotoxicity of rituximab. However, clinical data evaluating the interaction are not available and the significance of this effect is unknown.

MANAGEMENT: Until more information is available, caution and closer monitoring for decreased efficacy of rituximab is advised if the complement inhibitors eculizumab, ravulizumab, or zilucopan are used concurrently.

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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