Drug Interactions between ribociclib and stiripentol

Stiripentol should be taken during a meal to help with its absorption; however, it should not be taken with milk, dairy products (e.G., yogurt, soft cream cheese), fruit juice, or carbonated (fizzy) beverages. Also avoid or limit the use of alcohol because it can increase side effects of stiripentol such as dizziness and drowsiness. Patients should not engage in activities requiring mental alertness such as driving or operating hazardous machinery until they know how the medication affects them. Food and beverages that may contain caffeine or theophylline such as colas, chocolate, coffee, tea, or energy drinks should also be avoided, since stiripentol may affect the clearance of these substances from the body. Some medications may also contain caffeine, so check product labels to verify the ingredients before taking, or ask a pharmacist or other healthcare provider for assistance. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Patients should not consume pomegranates, pomegranate juice, grapefruit, or grapefruit juice during treatment with ribociclib unless directed otherwise by your doctor. Pomegranate juice or grapefruit juice can increase the blood levels of ribociclib. You may be more likely to experience side effects such as nausea; vomiting; diarrhea; loss of appetite; abdominal pain; mouth sores; hair loss; weakness; and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.