Drug Interactions between Reyataz and Viekira XR

Atazanavir is often used with ritonavir (brand name Norvir) to treat HIV infection. However, since ritonavir is one of the components of your hepatitis C medication, you do not need a separate dose of ritonavir with atazanavir if you are also receiving paritaprevir. The important thing is to take atazanavir in the morning, since only the morning doses of your hepatitis C medication contain ritonavir. Ask your doctor or pharmacist if you have any questions on how to take your medications properly. Another concern with respect to using atazanavir together with paritaprevir is the potential for increased risk of developing excessive bilirubin levels in the blood, which in severe cases can lead to seizures and brain damage. However, in clinical trials, bilirubin elevations usually resolved with continued treatment. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you notice yellowing of the skin or eyes, as it may indicate too much bilirubin in the circulation. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Using atazanavir together with ritonavir may increase the effects of atazanavir. Contact your doctor if you experience increased urination or extreme thirst, severe pain in your side or lower back, painful urination, blood in your urine, easy bruising or bleeding, signs of a new infection, such as fever or chills, cough, or flu symptoms, or jaundice (yellowing of the skin or eyes). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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