Drug Interactions between regorafenib and seladelpar

Regorafenib may increase the blood levels of seladelpar. This can increase the risk and/or severity of side effects such as changes in your liver tests, headache, stomach pain or swelling (distension), nausea, and/or dizziness. Your healthcare provider may already be aware of the risks, but has determined that this is the best course of treatment for you and is monitoring you closely for any potential complications. Speak with your healthcare provider right away if you develop any of the following signs or symptoms during treatment with seladelpar as they may indicate worsening liver problems: swelling of your stomach-area (abdomen) from a build-up of fluid, yellowing of your skin or the whites of your eyes, pain on the right side of your stomach, coughing or vomiting up blood or blood clots, red or black stools that look like tar, and/or mental changes like confusion, slurred speech, or changes in personality. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.