Drug Interactions between Rapamune and tacrolimus
This report displays the potential drug interactions for the following 2 drugs:
- Rapamune (sirolimus)
- tacrolimus
Interactions between your drugs
No interactions were found between Rapamune and tacrolimus. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Rapamune
A total of 680 drugs are known to interact with Rapamune.
- Rapamune is in the following drug classes: mTOR inhibitors, selective immunosuppressants.
- Rapamune is used to treat the following conditions:
tacrolimus
A total of 832 drugs are known to interact with tacrolimus.
- Tacrolimus is in the drug class calcineurin inhibitors.
-
Tacrolimus is used to treat the following conditions:
- Crohn's Disease (off-label)
- Graft-versus-host disease (off-label)
- Nephrotic Syndrome (off-label)
- Organ Transplant, Rejection Prophylaxis
- Organ Transplant, Rejection Reversal
Drug and food interactions
tacrolimus food
Applies to: tacrolimus
Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each day. Grapefruit and grapefruit juice may increase the amount of tacrolimus in your body. This can lead to potentially dangerous side effects and should be avoided. If you are already consuming grapefruit products, do not increase or decrease the amount of these products in your diet without first talking to your doctor.
sirolimus food
Applies to: Rapamune (sirolimus)
Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. Also, you should preferably take sirolimus at least one hour before eating. If you do take it with food, you should take it each time with food to avoid changes in sirolimus levels. The oral liquid form of sirolimus must be mixed with water or orange juice only. Do not use grapefruit juice to mix this medication.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Macrolide immunosuppressants
Therapeutic duplication
The recommended maximum number of medicines in the 'macrolide immunosuppressants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'macrolide immunosuppressants' category:
- Rapamune (sirolimus)
- tacrolimus
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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