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Drug Interactions between proguanil and Tegopen

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cloxacillin proguanil

Applies to: Tegopen (cloxacillin) and proguanil

ADJUST DOSING INTERVAL: The concomitant administration of proguanil may delay as well as decrease the gastrointestinal absorption of cloxacillin. The exact mechanism of interaction is unknown but may involve adsorption of cloxacillin to proguanil in the gastrointestinal tract, formation of a complex between the two drugs, or inhibition of gastric motility by proguanil, all of which may lead to reduction in bioavailability of cloxacillin. In seven healthy volunteers, coadministration of a single oral dose of proguanil (200 mg) and cloxacillin (500 mg) resulted in an approximately 50% decrease in both the rate and extent of cloxacillin absorption compared to administration of cloxacillin alone.

MANAGEMENT: To avoid potentially subtherapeutic plasma concentrations of cloxacillin during coadministration with proguanil, the drugs should probably be administered at least 1 to 2 hours apart.

References

  1. Babalola CP, Iwheye GB, Olaniyi AA (2002) "Effect of proguanil interaction on bioavailability of cloxacillin." J Clin Pharm Ther, 27, p. 461-4

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Drug and food interactions

Moderate

cloxacillin food

Applies to: Tegopen (cloxacillin)

ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food. The therapeutic effect of the antimicrobial may be reduced.

MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.

References

  1. Neu HC (1974) "Antimicrobial activity and human pharmacology of amoxicillin." J Infect Dis, 129, s123-31
  2. Welling PG, Huang H, Koch PA, Madsen PO (1977) "Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects." J Pharm Sci, 66, p. 549-52
  3. McCarthy CG, Finland M (1960) "Absorption and excretion of four penicillins." N Engl J Med, 263, p. 315-26
  4. Cronk GA, Wheatley WB, Fellers GF, Albright H (1960) "The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract." Am J Med Sci, 240, p. 219-25
  5. Klein JO, Sabath LD, Finland M (1963) "Laboratory studies on oxacillin. I: in vitro activity against staphylococci and some other bacterial pathogens. II: absorption and urinary excretion in normal young." Am J Med Sci, 245, p. 399-411
  6. Neuvonen PJ, Elonen E, Pentikainen PJ (1977) "Comparative effect of food on absorption of ampicillin and pivampicillin." J Int Med Res, 5, p. 71-6
View all 6 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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