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Drug Interactions between probenecid and zalcitabine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

probenecid zalcitabine

Applies to: probenecid and zalcitabine

MONITOR: Probenecid may increase plasma concentrations and decrease clearance of zalcitabine. The mechanism may be inhibition of renal tubular secretion of zalcitabine.

MANAGEMENT: Close clinical monitoring for evidence of zalcitabine toxicity (peripheral neuropathy, pancreatitis, lactic acidosis, hepatotoxicity) is recommended when these drugs are used together. In addition, a reduction in zalcitabine dosage may be warranted. Patients should be advised to promptly notify their physician if they experience numbness, tingling, severe nausea and vomiting, diarrhea, abdominal pain, severe fatigue, jaundice, or unusual bleeding or bruising.

References (1)
  1. Massarella JW, Nazareno LA, Passe S, Min B (1996) "The effect of probenecid on the pharmacokinetics of zalcitabine in HIV-positive patients." Pharmaceut Res, 13, p. 449-52

Drug and food interactions

Minor

zalcitabine food

Applies to: zalcitabine

Zalcitabine bioavailability may be decreased by 14% if taken with meals. The mechanism and clinical significance are unknown.

References (1)
  1. (2001) "Product Information. HIVID (zalcitabine)." Roche Laboratories

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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