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Drug Interactions between Pro-Med and trichophyton skin test

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

promethazine trichophyton skin test

Applies to: Pro-Med (promethazine) and trichophyton skin test

ADJUST DOSING INTERVAL: Systemic antihistamines may diminish the response to the trichophyton diagnostic skin test and lead to falsely insignificant or false-negative results. The proposed mechanism is inhibition of histamine release in the skin leading to suppression of the wheal and flare response. This interaction has been documented in numerous studies examining allergenic extracts and different antihistamines, but clinical data with the trichophyton diagnostic skin test are not readily available.

MANAGEMENT: The labeling for the trichophyton skin test recommends avoiding use of antihistamines for at least 24 hours prior to skin testing, though longer may be required depending on the specific antihistamine in question. Consultation with the labeling of the individual antihistamine as well as any relevant local and/or national guideline(s) is advisable.

References (2)
  1. (2007) "Product Information. Trichophyton Extracts (trichophyton skin test)." Allermed Laboratories Inc
  2. Bernstein L, Li JT, Bernstein DI, et al. (2008) "Allergy diagnostic testing: an updated practice parameter." Ann Allergy Asthma Immunol, 100, S1-148

Drug and food interactions

Moderate

promethazine food

Applies to: Pro-Med (promethazine)

GENERALLY AVOID: Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment. Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines. The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.

MANAGEMENT: Patients should be advised to avoid alcohol during phenothiazine therapy.

References (2)
  1. Lutz EG (1976) "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA, 236, p. 2422-3
  2. Freed E (1981) "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust, 2, p. 44-5

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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