Drug Interactions between Prevacid NapraPAC and viloxazine
This report displays the potential drug interactions for the following 2 drugs:
- Prevacid NapraPAC (lansoprazole/naproxen)
- viloxazine
Interactions between your drugs
naproxen lansoprazole
Applies to: Prevacid NapraPAC (lansoprazole / naproxen) and Prevacid NapraPAC (lansoprazole / naproxen)
GENERALLY AVOID: Theoretically, proton pump inhibitors may decrease the gastrointestinal absorption of enteric-coated naproxen, which requires an acidic environment for dissolution. The proposed mechanism is an increase in gastric pH (i.e. decreased gastric acidity) induced by proton pump inhibitors. In patients treated with proton pump inhibitors, the possibility of a reduced or subtherapeutic response to enteric-coated naproxen should be considered.
MANAGEMENT: Concomitant use of these drugs is generally not recommended.
References
- (2002) "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc
naproxen viloxazine
Applies to: Prevacid NapraPAC (lansoprazole / naproxen) and viloxazine
MONITOR: Coadministration with viloxazine, a potent CYP450 1A2 inhibitor may increase the plasma concentrations of CYP450 1A2 substrates leading to increased toxicity. According to the prescribing information, viloxazine increased the systemic exposure (AUC) of caffeine, a probe CYP450 1A2 substrate, by nearly 6-fold without affecting its peak plasma concentration (Cmax).
MANAGEMENT: Monitor for toxicities of CYP450 1A2 substrates whenever viloxazine is added to or withdrawn from therapy. Adjust doses of CYP450 1A2 substrates as clinically indicated.
References
- (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc
Drug and food interactions
naproxen food
Applies to: Prevacid NapraPAC (lansoprazole / naproxen)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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