Drug Interactions between posaconazole and Xalkori
This report displays the potential drug interactions for the following 2 drugs:
- posaconazole
- Xalkori (crizotinib)
Interactions between your drugs
posaconazole crizotinib
Applies to: posaconazole and Xalkori (crizotinib)
Consumer information for this interaction is not currently available.
CONTRAINDICATED: Coadministration with posaconazole may increase the plasma concentrations of CYP450 3A4 substrates that can prolong the QT interval, possibly resulting in QT prolongation and cases of torsade de pointes (TdP). The underlying mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by posaconazole. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).
MANAGEMENT: Coadministration of posaconazole with CYP450 3A4 substrates that can prolong the QT interval is considered contraindicated.
References
- "Product Information. Noxafil (posaconazole)." Schering-Plough Corporation (2006):
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
- "Product Information. Posaconazole (AKM) (posaconazole)." Pharmacor Pty Ltd (2022):
- "Product Information. Posaconazole (posaconazole)." Morningside Healthcare Ltd (2024):
- "Product Information. Posaconazole (posaconazole)." Eugia US LLC (2023):
- "Product Information. Gln-Posaconazole (posaconazole)." Glenmark Pharmaceuticals Canada Inc (2023):
Drug and food interactions
crizotinib food
Applies to: Xalkori (crizotinib)
Do not consume grapefruit or grapefruit juice during treatment with crizotinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of crizotinib to dangerous levels and cause an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with crizotinib. You may take crizotinib with or without food, but take it the same time each day. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
posaconazole food
Applies to: posaconazole
Food significantly increases the absorption of posaconazole from the tablet or suspension formulations. The manufacturer recommends that you take the tablet with food and the oral suspension during or immediately (within 20 minutes) after a full meal. If you cannot eat a full meal, you should take the oral suspension with a liquid nutritional supplement like Ensure or an acidic carbonated beverage like ginger ale. Do not take these medications on an empty stomach, as it may lead to inadequate blood levels and reduced effectiveness. Ask your doctor before using alcohol together with posaconazole from delayed release suspension formulations as this may cause an increase in side effects. Talk to your doctor or pharmacist if you have any questions on how to use the medication properly.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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