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Can you take Plasminogen, human with Protein c?

1 drug interaction and 3 additional warnings found for the following 2 drugs:

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Drug interactions

Major drug interactions

Major:

protein C plasminogen, human

Applies to: protein c and plasminogen, human

Using plasminogen, human together with protein C may increase the risk of bleeding.

Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications.

You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as:

  • dizziness
  • lightheadedness
  • red or black, tarry stools
  • coughing up or vomiting fresh or dried blood that looks like coffee grounds
  • severe headache
  • weakness

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease interactions

3 potential interactions Applies to: 3 conditions, including Bleeding Disorder, Renal Dysfunction, and Bleeding Associated with Coagulation Defect.

Bleeding Associated with Coagulation Defect

Moderate:

protein c

protein C has a moderate potential interaction with Bleeding Associated with Coagulation Defect.

In clinical studies, several bleeding episodes have been observed with the use of protein C concentrate human. Simultaneous administration of protein C concentrate human and tissue plasminogen activator (tPA) may further increase the risk of bleeding from tPA, specially in those at risk. Care should be taken when using this agent in patients at risk of bleeding.

Bleeding Disorder

Moderate:

protein c

protein C has a moderate potential interaction with Bleeding Disorder.

In clinical studies, several bleeding episodes have been observed with the use of protein C concentrate human. Simultaneous administration of protein C concentrate human and tissue plasminogen activator (tPA) may further increase the risk of bleeding from tPA, specially in those at risk. Care should be taken when using this agent in patients at risk of bleeding.

Renal Dysfunction

Moderate:

protein c

protein C has a moderate potential interaction with Renal Dysfunction.

Protein C concentrate human contains sodium >200 mg. Inform patients on a low sodium diet that the quantity of sodium in the maximum daily dose of protein C concentrate human exceeds 200 mg. Care should be exercised when using this agent in patients with renal impairment due to the risk of sodium overload or those on a low sodium diet.

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More resources

plasminogen, human

A total of 77 drugs are known to interact with plasminogen, human.

protein c

A total of 66 drugs are known to interact with protein c.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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