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Drug Interactions between phenylbutazone and Tri-Norinyl

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

ethinyl estradiol phenylbutazone

Applies to: Tri-Norinyl (ethinyl estradiol / norethindrone) and phenylbutazone

Using ethinyl estradiol together with phenylbutazone can alter the effects of ethinyl estradiol. Phenylbutazone can make birth control pills less effective, which may result in pregnancy. Before taking phenylbutazone, tell your doctor if you use birth control pills. If you are using oral contraceptives you should be advised of the risk of breakthrough bleeding and unintended pregnancy during phenylbutazone therapy. Alternative or additional methods of birth control should be used during and probably for at least one week after short-term and up to one month after long-term (greater than 4 weeks) phenylbutazone therapy. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylbutazone norethindrone

Applies to: phenylbutazone and Tri-Norinyl (ethinyl estradiol / norethindrone)

Using norethindrone together with phenylbutazone can alter the effects of norethindrone. Phenylbutazone can make birth control pills less effective, which may result in pregnancy. Before taking phenylbutazone, tell your doctor if you use birth control pills. If you are using oral contraceptives you should be advised of the risk of breakthrough bleeding and unintended pregnancy during phenylbutazone therapy. Alternative or additional methods of birth control should be used during and probably for at least one week after short-term and up to one month after long-term (greater than 4 weeks) phenylbutazone therapy. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

norethindrone food

Applies to: Tri-Norinyl (ethinyl estradiol / norethindrone)

Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norethindrone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Minor

ethinyl estradiol food

Applies to: Tri-Norinyl (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: Tri-Norinyl (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

norethindrone food

Applies to: Tri-Norinyl (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.