Drug Interactions between Pepto PM Gummies and Zepbound
This report displays the potential drug interactions for the following 2 drugs:
- Pepto PM Gummies (calcium phosphate, tribasic/melatonin)
- Zepbound (tirzepatide)
Interactions between your drugs
melatonin tirzepatide
Applies to: Pepto PM Gummies (calcium phosphate, tribasic / melatonin) and Zepbound (tirzepatide)
Tirzepatide may affect the absorption of oral medications, as it can delay the emptying of stomach content into the intestines. This may impact blood levels and/or the time that it takes for melatonin to become most effective, if melatonin is being administered by mouth or directly into the stomach via a feeding tube. These effects are most apparent at the start of treatment with tirzepatide or after a dose increase and tend to diminish the longer that you are on a stable regimen of tirzepatide. Contact your doctor if you have any questions or notice a change in how any of your oral medications are working. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
calcium phosphate, tribasic food
Applies to: Pepto PM Gummies (calcium phosphate, tribasic / melatonin)
Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
melatonin food
Applies to: Pepto PM Gummies (calcium phosphate, tribasic / melatonin)
Both smoking and excessive caffeine consumption can alter the blood levels of melatonin, which may affect the dosing. Tobacco smoking reduces, while caffeine increases melatonin blood levels. If you start smoking or undergo smoking cessation, your doctor may need to adjust the dose of melatonin. In addition, alcohol may reduce the effect of melatonin on sleep. It is best to avoid alcohol consumption during melatonin therapy. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
tirzepatide food
Applies to: Zepbound (tirzepatide)
Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases, this may affect how well and/or how fast those medications work, or it may make no difference. Talk to a healthcare provider if you have any questions or concerns, and contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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