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Drug Interactions between Pepcid Complete and Vitamin D3

This report displays the potential drug interactions for the following 2 drugs:

  • Pepcid Complete (calcium carbonate/famotidine/magnesium hydroxide)
  • Vitamin D3 (cholecalciferol)

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Interactions between your drugs

Moderate

magnesium hydroxide cholecalciferol

Applies to: Pepcid Complete (calcium carbonate / famotidine / magnesium hydroxide) and Vitamin D3 (cholecalciferol)

Using cholecalciferol together with magnesium hydroxide can lead to elevated magnesium blood levels, particularly in individuals with reduced kidney function. Symptoms of high magnesium levels may include nausea, vomiting, flushing, drowsiness, dizziness, confusion, muscle weakness, reduced reflexes, low blood pressure, slow heart rate, and impaired breathing. You should seek medical attention if you experience these symptoms. If you are on dialysis and treated with cholecalciferol or other vitamin D medications, you should generally avoid taking products that contain magnesium without first talking to your doctor, as high levels of magnesium over time can lead to bone problems. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

famotidine calcium carbonate

Applies to: Pepcid Complete (calcium carbonate / famotidine / magnesium hydroxide) and Pepcid Complete (calcium carbonate / famotidine / magnesium hydroxide)

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.

Minor

famotidine magnesium hydroxide

Applies to: Pepcid Complete (calcium carbonate / famotidine / magnesium hydroxide) and Pepcid Complete (calcium carbonate / famotidine / magnesium hydroxide)

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.

Drug and food interactions

Moderate

calcium carbonate food

Applies to: Pepcid Complete (calcium carbonate / famotidine / magnesium hydroxide)

Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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