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Can you take Paraldehyde with Quviviq?

1 drug interaction and 9 additional warnings found for the following 2 drugs:

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Drug interactions

Moderate drug interactions

Moderate:

paraldehyde daridorexant

Applies to: paraldehyde and Quviviq (daridorexant)

Using paraldehyde together with daridorexant may increase side effects such as:

  • dizziness
  • drowsiness
  • confusion
  • difficulty concentrating

Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

What to do: You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you.

Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition.

It can be intentional, when combining drugs with similar actions adds demonstrated therapeutic benefit — or unintentional, such as when a patient sees multiple prescribers or fills prescriptions at more than one pharmacy, which can lead to adverse effects.

Duplication:

Hypnotics

The recommended maximum number of medicines in the 'hypnotics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'hypnotics' category:

  • paraldehyde
  • Quviviq (daridorexant)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

Food/lifestyle interactions

Moderate food/lifestyle interactions

Moderate:

paraldehyde Food/Lifestyle

Applies to: paraldehyde

Alcohol can increase the nervous system side effects of paraldehyde such as:

  • dizziness
  • drowsiness
  • difficulty concentrating

Some people may also experience impairment in thinking and judgment.

You should avoid or limit the use of alcohol while being treated with paraldehyde.

Do not use more than the recommended dose of paraldehyde, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.

Talk to your doctor or pharmacist if you have any questions or concerns.

Moderate:

daridorexant Food/Lifestyle

Applies to: Quviviq (daridorexant)

Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with daridorexant unless directed otherwise by your doctor.

Grapefruit juice can increase the blood levels of daridorexant. This may increase the risk of side effects such as:

  • somnolence
  • fatigue
  • abnormal sleep behaviors
  • worsening of depression or suicidal thoughts
  • headache

You should avoid the use of alcohol while being treated with daridorexant. Alcohol can increase the nervous system side effects of daridorexant such as:

  • dizziness
  • drowsiness
  • reduced coordination

Some people may also experience complex sleep behaviors such as sleepwalking, sleep driving, preparing and eating food or doing other activities while not fully awake that you may not remember the next morning.

Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Disease interactions

6 potential interactions Applies to: 6 conditions, including Depression, Narcolepsy, Drug Dependence, Liver Disease, and Alcoholism.

Alcoholism

Moderate:

Quviviq

The daridorexant in Quviviq has a moderate potential interaction with Alcoholism.

Patients with a history of abuse or addiction to alcohol or other substances may be at increased risk for abuse of or addiction to daridorexant and should be monitored closely.

Depression

Moderate:

Quviviq

The daridorexant in Quviviq has a moderate potential interaction with Depression.

Daridorexant can worsen depression and suicidal thoughts and actions and should be used with caution in patients with depression. These patients should be monitored closely and any preventive measures should be taken.

Drug Dependence

Moderate:

Quviviq

The daridorexant in Quviviq has a moderate potential interaction with Drug Dependence.

Patients with a history of abuse or addiction to alcohol or other substances may be at increased risk for abuse of or addiction to daridorexant and should be monitored closely.

Liver Disease

Moderate:

Quviviq

The daridorexant in Quviviq has a moderate potential interaction with Liver Disease.

Daridorexant is not recommended in patients with severe hepatic dysfunction. The maximum recommended dosage in patients with moderate hepatic dysfunction is 25 mg once per night.

Narcolepsy

Major:

Quviviq

The daridorexant in Quviviq has a major potential interaction with Narcolepsy.

Daridorexant is contraindicated in patients with narcolepsy.

Pulmonary Impairment

Moderate:

Quviviq

The daridorexant in Quviviq has a moderate potential interaction with Pulmonary Impairment.

Daridorexant is a respiratory depressant and should be used with caution if prescribed to patients with impaired respiratory function. This drug has not been studied in patients with moderate to severe sleep apnea requiring CPAP or in patients with severe chronic obstructive pulmonary disease (COPD).

More resources

paraldehyde

A total of 357 drugs are known to interact with paraldehyde.

Quviviq

A total of 779 drugs are known to interact with Quviviq.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.