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Drug Interactions between pancuronium and Thioplex

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

pancuronium thiotepa

Applies to: pancuronium and Thioplex (thiotepa)

MONITOR: The neuromuscular blocking effects of pancuronium may be increased in patients concurrently receiving thiotepa, and apnea may occur. The mechanism is not known.

MANAGEMENT: If these agents are to be used concurrently, close monitoring of neuromuscular function and respiration is recommended.

References (2)
  1. Bennett EJ, Schmidt GB, Patel KP, Grundy EM (1977) "Muscle relaxants, myasthenia, and mustards?" Anesthesiology, 46, p. 220-1
  2. Rylett BJ, Colhoun EH (1977) "Effects of acetylcholine mustard aziridinium ion and its choline analogue on choline transport into synaptosomes." Can J Physiol Pharmacol, 55, p. 769-72

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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