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Drug Interactions between ospemifene and Xenical

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

orlistat ospemifene

Applies to: Xenical (orlistat) and ospemifene

MONITOR: Coadministration of orlistat with ospemifene may result in a reduction in the bioavailability and therapeutic effects of ospemifene. By partially inhibiting the absorption of dietary fat, orlistat may indirectly reduce the gastrointestinal absorption of ospemifene, which is lipophilic in nature.

MANAGEMENT: Caution is advised if orlistat and ospemifene are used in combination. Patients should be monitored for clinical evidence of altered ospemifene efficacy. Separating the doses of orlistat and ospemifene by at least 2 hours may help minimize the potential for an interaction.

References (1)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Drug and food interactions

Moderate

ospemifene food

Applies to: ospemifene

ADJUST DOSING INTERVAL: Food significantly enhances the oral bioavailability of ospemifene. In a cross-study comparison, administration of a single 60 mg dose of ospemifene with a high-fat/high-calorie meal (860 kcal) in postmenopausal women increased ospemifene peak plasma concentration (Cmax) and systemic exposure (AUC) by 2.3- and 1.7-fold, respectively, compared to administration under fasted condition. Elimination half-life and time to maximum concentration (Tmax) were not altered. In two separate food effect studies where different ospemifene tablet formulations were given to healthy male volunteers, ospemifene Cmax and AUC increased by 2.3- and 1.8-fold, respectively, with a low-fat/low-calorie meal (300 kcal) and 3.6- and 2.7-fold, respectively, with a high-fat/high-calorie meal (860 kcal) relative to fasting.

MANAGEMENT: Ospemifene should be taken once daily with food.

References (1)
  1. (2013) "Product Information. Osphena (ospemifene)." Shionogi USA Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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