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Drug Interactions between opicapone and solriamfetol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

opicapone solriamfetol

Applies to: opicapone and solriamfetol

MONITOR: Coadministration of solriamfetol with other drugs that increase dopamine levels or that bind directly to dopamine receptors may increase the risk of dopaminergic-related adverse effects. The mechanism of the interaction has not been reported, but it may involve synergistic or additive central dopaminergic effects. This interaction has not been evaluated clinically.

MANAGEMENT: Caution is advised if solriamfetol is administered concomitantly with other dopaminergic drugs. Dosage adjustments and close patient monitoring should be considered whenever solriamfetol is used with other dopaminergic drugs.

References (1)
  1. (2019) "Product Information. Sunosi (solriamfetol)." Jazz Pharmaceuticals

Drug and food interactions

Moderate

opicapone food

Applies to: opicapone

ADJUST DOSING INTERVAL: Food may reduce the rate and extent of absorption of opicapone. When opicapone was administered following a moderate fat/moderate calorie meal, mean opicapone peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 62% and 31%, respectively, while the time to reach peak concentration (Tmax) was delayed by 4 hours.

MANAGEMENT: Patients should avoid eating 1 to 2 hours before and after taking opicapone.

References (2)
  1. Cerner Multum, Inc. "Australian Product Information."
  2. (2020) "Product Information. Ongentys (opicapone)." Neurocrine Biosciences, Inc.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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