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Drug Interactions between ofloxacin and Polycitra

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

ofloxacin potassium citrate

Applies to: ofloxacin and Polycitra (citric acid/potassium citrate/sodium citrate)

Talk to your doctor before using potassium citrate together with ofloxacin. Potassium citrate can change the acidity of your urine, which may cause ofloxacin to crystallize and form stones. This may also occur if you are dehydrated, so you should drink plenty of fluids during treatment with ofloxacin. Let your doctor know if you experience flank pain, painful urination, or blood in the urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

ofloxacin citric acid

Applies to: ofloxacin and Polycitra (citric acid/potassium citrate/sodium citrate)

Talk to your doctor before using citric acid together with ofloxacin. Citric acid can change the acidity of your urine, which may cause ofloxacin to crystallize and form stones. This may also occur if you are dehydrated, so you should drink plenty of fluids during treatment with ofloxacin. Let your doctor know if you experience flank pain, painful urination, or blood in the urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

ofloxacin sodium citrate

Applies to: ofloxacin and Polycitra (citric acid/potassium citrate/sodium citrate)

Talk to your doctor before using sodium citrate together with ofloxacin. Sodium citrate can change the acidity of your urine, which may cause ofloxacin to crystallize and form stones. This may also occur if you are dehydrated, so you should drink plenty of fluids during treatment with ofloxacin. Let your doctor know if you experience flank pain, painful urination, or blood in the urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food/lifestyle interactions

Moderate

ofloxacin food/lifestyle

Applies to: ofloxacin

Consumer information for this interaction is not currently available.

GENERALLY AVOID: The oral bioavailability of quinolone and tetracycline antibiotics may be reduced by concurrent administration of preparations containing polyvalent cations such as aluminum, calcium, iron, magnesium, and zinc. Therapeutic failure may result. The proposed mechanism is chelation of quinolone and tetracycline antibiotics by di- and trivalent cations, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. Reduced gastrointestinal absorption of the cations should also be considered.

MANAGEMENT: Concomitant administration of oral quinolone and tetracycline antibiotics with preparations containing aluminum, calcium, iron, magnesium, and/or zinc salts should generally be avoided. Otherwise, the times of administration should be staggered by as much as possible to minimize the potential for interaction. Quinolones should typically be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation preparations, depending on the quinolone and formulation. Likewise, tetracyclines and polyvalent cation preparations should typically be administered 2 to 4 hours apart. The prescribing information for the antibiotic should be consulted for more specific dosing recommendations.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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