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Drug Interactions between Niaspan and sulfinpyrazone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

niacin sulfinpyrazone

Applies to: Niaspan (niacin) and sulfinpyrazone

Niacin may reduce the uricosuric effect of sulfinpyrazone. The mechanism is not entirely clear, but probably involves reduction of the inhibitory effect of sulfinpyrazone on renal tubular reabsorption of uric acid. Since hyperuricemia is a potential side effect of niacin, an alternative antihyperlipidemia agent should be used.

References

  1. Gershon SL, Fox IH (1974) "Pharmacologic effects of nicotinic acid on human purine metabolism." J Lab Clin Med, 84, p. 179-86

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Drug and food interactions

Moderate

niacin food

Applies to: Niaspan (niacin)

GENERALLY AVOID: Ethanol can exacerbate the cutaneous flushing that is a common side effect of niacin. At least one case of delirium and lactic acidosis has been reported with coadministration of these drugs, although data are limited.

MANAGEMENT: Coadministration should probably be discouraged, particularly since chronic consumption of large amounts of alcohol is associated with hyperlipidemia.

References

  1. Schwab RA, Bachhuber BH (1991) "Delirium and lactic acidosis caused by ethanol and niacin coingestion." Am J Emerg Med, 9, p. 363-5

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Minor

niacin food

Applies to: Niaspan (niacin)

A single case has been reported in which cutaneous flushing and tremors were noted in a woman who was taking niacin while wearing a nicotine patch. The mechanism is suspected to be synergistic cutaneous vasodilatory effects. The clinical significance of this possible interaction is not known.

References

  1. Rockwell KA Jr (1993) "Potential interaction between niacin and transdermal nicotine." Ann Pharmacother, 27, p. 1283-8

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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