Drug interactions between Nexium and tacrolimus
Interactions between your drugs
tacrolimus ↔ esomeprazole
Applies to:tacrolimus and Nexium (esomeprazole)
Using esomeprazole together with tacrolimus may cause a condition called hypomagnesemia, or low blood magnesium. Drugs known as proton pump inhibitors including esomeprazole can cause hypomagnesemia when used for a prolonged period, and the risk may be further increased when combined with other medications that also have this effect such as tacrolimus. In severe cases, hypomagnesemia can lead to irregular heart rhythm, palpitations, muscle spasm, tremor, or seizures. Additionally, esomeprazole may increase the blood levels of tacrolimus in some people. This may increase the risk of serious side effects such as diabetes, infections, kidney damage, high blood potassium (hyperkalemia), tremor, seizures, visual disturbances, high blood pressure, and heart enlargement. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. If you are using an over-the-counter proton pump inhibitor medication such as Prilosec OTC, Zegerid OTC or Prevacid 24 HR, you should follow the directions on the package carefully. Do not use the medication more frequently or for a longer period than recommended on the label unless otherwise prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
Applies to: tacrolimus
Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each day. Grapefruit and grapefruit juice may increase the amount of tacrolimus in your body. This can lead to potentially dangerous side effects and should be avoided. If you are already consuming grapefruit products, do not increase or decrease the amount of these products in your diet without first talking to your doctor.
Applies to: Nexium (esomeprazole)
Food may interfere with the absorption of esomeprazole. Esomeprazole should be taken at least one hour before meals and at the same time every day. When esomeprazole is given to patients receiving continuous enteral nutrition (tube feedings), the tube feeding should be interrupted for at least 1 hour before and 1 hour after the dose of esomeprazole. This will make it easier for your body to absorb the medication. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
Drug Interaction Classification
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.