Skip to main content

Drug Interactions between nevirapine and rifabutin

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Minor

rifabutin nevirapine

Applies to: rifabutin and nevirapine

Rifabutin may modestly reduce plasma concentrations of nevirapine (by 16%). The mechanism is induction of CYP450 3A4 hepatic metabolism. Data are insufficient to determine the clinical significance or whether dosage adjustments are necessary. The manufacturer recommends that these drugs should be used in combination with caution and only if clearly indicated. Patients should be monitored for altered therapeutic effect.

References (4)
  1. (2001) "Product Information. Viramune (nevirapine)." Boehringer-Ingelheim
  2. Burman WJ, Jones BE (2001) "Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy." Am J Respir Crit Care Med, 164, p. 7-12
  3. (2000) "Notice to readers: updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibiotrs." MMWR Morb Mortal Wkly Rep, 49, p. 185-9
  4. Back D, Gibbons S, Khoo S (2003) "Pharmacokinetic drug interactions with nevirapine." J Acquir Immune Defic Syndr, 34 Suppl 1, S8-14

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer