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Drug Interactions between nevirapine and prasugrel

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

nevirapine prasugrel

Applies to: nevirapine and prasugrel

Coadministration with prasugrel may alter the metabolism of drugs that are substrates of CYP450 2B6. Prasugrel is a weak inhibitor of the isoenzyme. In healthy subjects, prasugrel decreased systemic exposure to hydroxybupropion, a CYP450 2B6-mediated metabolite of bupropion, by 23%. This change is not considered clinically significant. Therefore, prasugrel is not anticipated to have a significant effect on the pharmacokinetics of drugs that are primarily metabolized by CYP450 2B6 such as cyclophosphamide, efavirenz, halothane, nevirapine, propofol, selegiline, and tamoxifen.

References (2)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. (2009) "Product Information. Effient (prasugrel)." Lilly, Eli and Company

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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