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Drug Interactions between Naropin Polyamp and tacrine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

tacrine ROPivacaine

Applies to: tacrine and Naropin Polyamp (ropivacaine)

Ropivacaine serum concentrations may increase when given with drugs metabolized by the CYP450 isoenzyme 1A2. The theorized mechanism is via competitive inhibition. Information is only available from in-vitro studies. The clinical significance is unknown. Consider monitoring the patient more closely for prolonged or excessive ropivacaine effects if these agents are coadministered.

References

  1. "Product Information. Naropin (ropivacaine)." Astra-Zeneca Pharmaceuticals PROD (2001):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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