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Drug interactions between Myfortic and Neoral

Results for the following 2 drugs:
Myfortic (mycophenolic acid)
Neoral (cyclosporine)

Interactions between your drugs


cyclosporine ↔ mycophenolic acid

Applies to:Neoral (cyclosporine) and Myfortic (mycophenolic acid)

Coadministration with cyclosporine has been shown in some studies to decrease serum levels of mycophenolic acid (MPA), and MPA levels have also increased significantly after discontinuation of cyclosporine. The mechanism and clinical significance are unknown. It may be appropriate to monitor for alterations in therapeutic effect and MPA trough levels whenever cyclosporine is added to or discontinued from the patient's immunosuppressant regimen. Mycophenolic acid has been shown to have no effect on the pharmacokinetics of cyclosporine in stable renal transplant patients.


  1. "Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals, East Hanover, NJ.
  2. Bornhauser M, Schuler U, Porksen G, Naumann R, Geissler G, Thiede C, Schwerdtfeger R, Ehninger G, Thiede HM "Mycophenolate mofetil and cyclosporine as graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation." Transplantation 67 (1999): 499-504
  3. Gregoor PJ, De Sevaux RG, Hene RJ, et al. "Effect of cyclosporine on mycophenolic acid trough levels in kidney transplant recipients." Transplantation 68 (1999): 1603-6

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Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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