Skip to main content

Drug Interactions between momelotinib and propofol

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

propofol momelotinib

Applies to: propofol and momelotinib

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of momelotinib may increase the plasma concentrations and effects of drugs that are substrates of CYP450 2B6. The proposed mechanism, based on in vitro data, is decreased drug clearance due to momelotinib-mediated inhibition of the CYP450 2B6 isoenzyme. However, clinical data are not available.

MANAGEMENT: Caution is advised if the momelotinib is administered with sensitive substrates of CYP450 2B6. Patients should be monitored for the development of adverse effects. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever momelotinib is added to or withdrawn from therapy with these drugs. Individual product labeling for the coadministered drug may also be consulted for specific guidance.

Drug and food/lifestyle interactions

Moderate

propofol food/lifestyle

Applies to: propofol

Alcohol can increase the nervous system side effects of propofol such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with propofol. Do not use more than the recommended dose of propofol, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer